The deceased was identified as Sheikh Imlam Pavel, 22, son of Monir Hossain, hailing from Keshobpur village in Baufol Upazila of Patuakhali district.
Pavel and his friend Belal Hossain locked into an altercation with Tuhin and Shahin, residents of the area, early Sunday over stalking of Pavel's sister.
At one stage, Tuhin and Shahin became furious and stabbed Pavel indiscriminately, leaving him severely injured.
Later, the injured was rushed to Dhaka Medical College Hospital (DMCH) where doctors declared him dead around 9:30 am.
Officer-in-charge of Shyampur Police Station Mizanur Rahman said police are conducting drive to arrest the youths.