Moderna’s vaccine ‘effective’ against new coronavirus variants...

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Moderna’s vaccine ‘effective’ against new coronavirus variants

 International Desk

 Published: 11:28 AM, 26 January 2021   Updated: 11:29 AM, 26 January 2021

File Photo

File Photo

Moderna, the United States-based biotech company, claimed that its COVID-19 vaccine is effective against new, more infectious variants of the pandemic virus found in the UK and South Africa. 

Early laboratory tests suggest antibodies triggered by the vaccine can recognise and fight the new variants. More studies are needed to confirm this is true for people who have been vaccinated.  

In a press release on Monday, Moderna said that the move was out of “an abundance of caution” after preliminary lab tests suggested its shot produced a weaker immune response to that variants. 

“We are encouraged by these new data, which reinforce our confidence that the Moderna COVID-19 Vaccine should be protective against these newly detected variants,” said Moderna’s CEO Stephane Bancel.

“Out of an abundance of caution and leveraging the flexibility of our mRNA platform, we are advancing an emerging variant booster candidate against the variant first identified in the Republic of South Africa into the clinic to determine if it will be more effective to boost titers against this and potentially future variants.” 

The new variants have been spreading fast in a number of nations. They have undergone changes or mutations that mean they can infect human cells more easily than the original version of coronavirus that started the pandemic. Experts think the UK strain, which emerged in September, may be up to 70% more transmissible. 

Current vaccines were designed around earlier variants, but scientists believe they should still work against the new ones, although perhaps not quite as well. There are already some early results that suggest the Pfizer vaccine protects against the new UK variant.

For the Moderna study, researchers looked at blood samples taken from eight people who had received the recommended two doses of the Moderna vaccine.

The findings are yet to be peer-reviewed but suggest immunity from the vaccine recognises the new variants. Neutralising antibodies, made by the body's immune system, stop the virus from entering cells.

Blood samples exposed to the new variants appeared to have sufficient antibodies to achieve this neutralising effect, although it was not as strong for the South Africa variant as for the UK one. 

Moderna says this could mean that protection against the South Africa variant might disappear more quickly.

Prof Lawrence Young, a virus expert at Warwick Medical School in the UK, said this would be concerning.

Moderna is currently testing whether giving a third booster shot might be beneficial. Like other scientists, the company is also investigating whether redesigning the vaccine to be a better match for the new variants will be beneficial.

UK regulators have already approved Moderna's vaccine for rollout on the NHS, but the 17m pre-ordered doses are not expected to arrive until Spring.

The vaccine works in a similar way to the Pfizer one already being used in the UK. More than 6.3 million people in the UK have already received the first dose of either the Pfizer or the AstraZeneca vaccine.