George Bush Sr, as he was known, passed away on Friday evening, a statement said on behalf of the family.
He was a World War Two aviator and Texan oil tycoon before entering politics in 1964 as a Republican.
In April, he was admitted to a hospital intensive care unit with an infection, a week after the death of his wife Barbara.
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Bush was admitted to Houston Methodist Hospital with a blood infection on April 22 -- two days after the funeral for his wife of 73 years, former first lady Barbara Bush.
He is survived by his five children, including former President George W. Bush and former Florida Gov. Jeb Bush.
Bush was with there his wife when she died at the age of 92 on April 17.
"He, of course, is broken-hearted to lose his beloved Barbara, his wife of 73 years. He held her hand all day and was at her side when [she] left this good earth, “a statement from his office said after her death. "But it will not surprise all of you who know and love him that he also is being stoic and strong, and is being lifted up by his large and supportive family.”